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Gomathi, S.
- Pedalium murex Linn Leaves against LPS-Induced Oxidative Stress, Anxiety and Depression Behavioural Alterations in Rats
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
2 Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
3 Department of Pharmaceutics, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
1 Department of Pharmaceutical Chemistry, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
2 Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
3 Department of Pharmaceutics, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1333-1338Abstract
Background: Studies of antioxidant substances in foods and natural products have gained increasing interest. The prevalence of neurodegenerative diseases are increasing globally. Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders. Objective: The present study was aimed to evaluate the neuroprotective effect of ethanol extract of Pedalium murex Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia. Materials and Methods: Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The neuroprotective activity was investigated following LPS-induced endotoxemia and then subjecting the animals to a battery of behavioural tests such as open field test (OFT), elevated plus-maze (EPM) and forced swim test (FST) to test anxiety and depression. At the end of the study, rats were sacrificed, brain hippocampal region was isolated and biochemical parameters were analysed. Results: These results highlight the neuroprotective potential of EEPM in LPS-induced anxiety and depressive illness model which may be partially due to inhibition of oxidative stress-neuroinflammatory cascade. Conclusion: The present study proved that EEPM has promising anti-anxiety, antidepressant action and can be potential candidates for the management of LPS-induced neurodegeneration.Keywords
Anxiety, Depression, Lipopolysaccharide, Oxidative Stress, Neuroprotection.
- Anti-Cancer Activity of Aloe Vera Ethanolic Leaves Extract against In vitro Cancer Cells
Abstract Views :196 |
PDF Views:0
Authors
T. Karpagam
1,
Jannathul Firdous
2,
Revathy
1,
Shanmuga Priya
1,
B. Varalakshmi
1,
S. Gomathi
1,
S. Geetha
3,
Noorzaid Muhamad
2
Affiliations
1 Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, IN
2 Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, MY
3 Biochemistry Department, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, IN
1 Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, IN
2 Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, MY
3 Biochemistry Department, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2167-2170Abstract
In the present study, anticancer and cytotoxicity of Aloe vera ethanolic leaves extract was evaluated as the leaves of A.vera are reported to have great medicinal value with potential therapeutic applications. The anticancer activities of the ethanolic leaves extract of A.vera were investigated using 3-(4,5-dimethylthiazole-2yl)-2,5-diphenyl tetrazolium bromide assay on three human cancer cell lines HepG2 (liver cancer), HeLa (human cervical carcinoma cell line) and A549 (human lung adenocarcinoma epithelial cell line).In anticancer studies, A.vera ethanolic leaves extract showed potent proliferation inhibitory activity against HepG2, HeLa and A549 cell lines. The results have shown that the A.vera ethanolic leaves extract contain some active ingredients with the potential of being anticancer agents. A.vera ethanolic leaves extract has the potential to fight against cancer cells. Further work should be carried out on the characterization of specific anticancer components of A.vera.Keywords
Aloe vera, Cancer cell lines, Lipid peroxidation, MTT assay, Phytochemicals.References
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